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It was patented in 1996 by Pfizer, and introduced for the first time on the market in 1998. Trade name of Viagra comes from sanskryckiego word wjaghra (Devanagari: व्याघ्र), identifying the tiger [1]. When you find a method to circumvent the patent Pfizera in this connection, it began to produce many companies in the world. Some of these are generic Kamagra (Ajanta Pharma) and the Polish Maxigra (Polpharma). There are also preparations wardenafilu (Levitra, Bayer) and tadalafilu (Cialis, Lilly) for similar action. Sildenafilu tablets contain 25 to 100 milligrams citrate this connection. The mechanism of action sildenafilu is inhibiting the enzyme fosfodiesterazy type 5 (PDE5) (affinity for other fosfodiesteraz is much smaller: PDE3 - more than 4,000 times, PDE 2, 3, 4, 7, 8, 9, 10, 11 - more than 700 times, PDE1 - 80 times, PDE 6 - 10 times). The molecule contains a recital sildenafilu piperazine and structural analogue of the principle of heterocyclic nukleozydowej, guanine - 1H-pyrazol [4.3-d] pirymidynę. Central phenolic system is structurally equivalent ribose, while the rest corresponds to the sulpho nucleotide phosphate. Desirable to take action Viagra leaflet with information about the proper use of medicine In people with a medical indication of sildenafil makes it possible to achieve sustainable wzwodu allowing completion of satisfactory sexual intercourse. Erection does not appear automatically after taking the medicine, but requires the erection normal sexual stimulation, which is its great advantage as compared with prostaglandin preparations. Keep eat from hours to 6 hours before the scheduled time relationship. In people with difficulties in erekcją doctor assesses the degree and nature of these difficulties and if they are actually a neurological psychiczno-recommended dose of the medicine that causes the persistence of wzwodu the normal time for a healthy man - that is, from 30 minutes to an hour. The medicine does not help people who have difficulty with erection different nature, for example resulting from the disappearance of the bodies of jamistych penis or low blood pressure. Another indication for use sildenafilu are selected cases of pulmonary hypertension. It has been shown that sildenafil can reduce the symptoms of pulmonary hypertension and improve tolerance effort. It is used when patients of all ages - including infants who have pulmonary hypertension may occur in the course of congenital heart defects. However, keep in mind about the possibility of complications of the treatment of blindness, including (vide contraindications). In a study SUPER, demonstrated significant improvement in the capacity stress in patients taking sildenafil at a dose of 20, 40 or 80 milligrams 3 times a day and this effect was independent of the applied dose of [2]. In Europe, the medicine has been registered for the treatment of pulmonary hypertension in functional class III and run as a form of idiopathic or connective tissue diseases [source needed]. Sildenafil at doses registered for the treatment of pulmonary hypertension is called Revatio. In two large randomized clinical trials on a group of 781 women with sexual dysfunction from normal (577 patients) and reduction (204 patients) the level of estrogen, there were no clinically significant improvement after taking doses sildenafilu (10-100 mg) compared with placebo. Contraindications It is contraindicated in the following diseases and states: * Ischemic heart disease, * Low blood pressure (less than 90/50 mmHg), * Simultaneous use of drugs from the group nitratów (nitrogliceryny, monoazotanu and diazotanu izosorbidu) * Allergic to sildenafil, * Severe liver and kidney failure, * After recently covered by the stroke or myocardial infarction, * In retinal degenerative changes, such as retinitis pigmentosa. Caution should be exercised in the following cases: * In patients with anatomical defects penis (Peyroniego disease, the bodies of jamistych fibrosis), * Patients treated ritonawirem, * Patients receiving α-adrenolityki, * In patients with a tendency to priapizmu (sickle cell anemia, multiple myeloma, other). Medicine should not be used in people from 18 years of age. This is a category B drug, which means that it is not intended for use in women, especially pregnant and lactating mothers. Side effects Side effects occur relatively infrequently, and these are not the most prevalent serious: * Headache, * Muscle pain, * Nausea, * Vomiting, * Feeling clogged nose, * Feeling hot in the vicinity of the face, * Transient visual disturbances, More serious side effects occur very rarely. Dyspeptyczne disorders, headaches and skin redness napadowe face combined with a feeling of hot (flushing) associated with the inhibition of fosfodiesterazy type 5 Due to the fact that sildenafil is blocking the enzyme retinal rodopsynazę (fosfodiesterazę type 6) side-effect of consumption sildenafilu may be changes in the reception colors (blue vision) [4]. On the other hand, due to the fact that fosfodiesteraza is present in all smooth muscles, including the heart, in patients with cardiac arrhythmia, hypertension and their tendency to zawałów, especially in combination with other drugs affecting the secretion of nitric oxide by the sympathetic nervous system, can claim to serious complications including myocardial infarction and death. The mechanism of drug action The mechanism of action sildenafilu At the time of the sexual arousal the brain sends a signal to the spinal nerve cells in the penis, controls the action of smooth muscle, which normally restrict the flow of blood through arteries to the penis jamistych bodies. Nerve cells, after receiving a signal from the brain, are beginning to produce nitric oxide. The smooth muscle is marked by a constant concentration of chemical compound - guanozyny triphosphate (GTP), and enzyme - guanozynowa cyclase. The enzyme is activated by nitric oxide produced by nerve cells. When activated, the enzyme that converts GTP in cGMP (cyclic monofosforan guanozyny). cGMP runs a string of change leading to a loosening of smooth muscle, thereby increasing the inflow of blood to the body jamistych member and his wzwodu. As long as the concentration of cGMP is maintained at a sufficiently high level, smooth muscle is relaxed, a member in erection. cGMP, however, is under normal conditions, constantly transformed by another enzyme - fosfodiesterazę - in the inactive GMP (plain monfosforan guanozyny). Hence the persistence of the penis is conditioned wzwodu constant cGMP production, and hence a constant delivery of nitric oxide by nerve cells, which must be driven by the brain. Many men, however, as a result of neuroses, mental tension, hormonal imbalances, or nervous system disorders współczulnego, production of nitric oxide by the nerve cell is too weak or short-term, leading to a weak and too short-term erections. Sildenafil works by inhibiting an enzyme fosfodiesterazy. Sildenafil has a geometric shape similar to cGMP and well located in the center of the active fosfodiesterazy, however, involves the fosfodiesterazą for a long time, blocking the opportunity to catalyze the transition cGMP in normal GMP. As a result, even small "production" NO by nerve cells is sufficient to achieve the appropriate concentration of cGMP, and can maintain it even without the continued production of nitric oxide by these cells. However, thanks to the fact that sildenafil acts on the "final" stage of the process, it does not automatically wzwodu, but still needed for this is "normal" erotic stimulation. Some call it love pill, others extasy for pensioners and others seksaspiryną. Blue pills have become VGR and are sold in the U.S. since April. And since that time America become fools. Apparently the name of this specyfiku is most frequently mentioned word in the U.S., after "Titanic." Since the launch of June the doctors prescribed medicines more than 1.5 million patients. Ladies and gentlemen, is our hero evening - Viagra, the impotence drug manufactured by Pfizer company. Available only on prescription. Viagra has become a dream of all men, not just numbers of 140 million suffer from impotence (estimates from around the world). You see him as healthy simply wonderful aphrodisiac. Wonderful, because it is simple to use - just swallow the pill, you do not need to take suppositories, injections done in the dead organ. Incredible, I work on average 70% of cases, and gives relatively few side effects - sometimes headache, nausea, and now famous "blue vision". For the healthy option seems to be crazy nights, ticket to the furthest recesses of the land of Eros, although experts do not recommend it to them. For many, Viagra has become a product of primary necessity, not from today known fact that men's sexual life is of utmost importance to them. For media information sensational mix of serious studies. "Corporate bags with the word Viagra can carry only one way - saying to yourself, otherwise we are beset by amateurs that specyfiku" - complain American Pfizer sales representatives. In turn, the Middle East, Lebanese Islamists sell Viagra Israeli soldiers, thus breaking the boundaries of an armed conflict. In Israel, during the deliberations of the Parliamentary Committee on Science, which discussed the release of Viagra for sale in strange circumstances went missing drug samples ... Italy blue already sells ice cream Viagra is a cheese of the same name. Viagro wave reached in May this year. to Germany. Many of the German past sexual began suddenly retired (not to write "the rape") to search for mates. From western neighbors is just a step to the Polish, and our analysts assess the market as the fastest growing pharmaceutical market in Europe. Viagra in Europe is to be officially released for sale until the autumn. But demand is largely built on the myth, which is shrouded in tablet, is already huge. Europeans can buy it in pharmacies in importing drugs from abroad. Unfortunately, the prices are high, for example in Germany for 30 tablets you need to pay about 1400 DEM (25 euro per tablet). In the U.S., where retail sales are legal, the price is $ 10 per pill (9 euro), and large, open around the clock, supermarkets can now buy 5 pills for $ 40 (7 europer tablet). No wonder that the black market outside the U.S. is growing exponentially. And so in Egypt, where Viagra is prohibited drug, one tablet costs $ 60. In France, 13 tablets is $ 500 expense (30 euro per tablet). Have provided a good business sales companies in cyberspace, where borders are not yet in force. On the Internet there were many parties, so that you can order Viagra. BEST ON THE INTERNET? In the article "Era of Viagra" the May "On" provides: "The cheapest and easiest way to buy the blue pill is the Internet." Well, yes - it seems logical, but is thirsty thing People may really be - this way - so easy to buy? We will see: In the first place I look on the mailing lists and notice boards. The list appeared pl.soc.seks.towarzyskie announcement about the content: "Buy Viagra, e-mail tel :..., ...". After two days of sending a letter of inquiry, I get the answer, that all information on the medicine are available by phone ... In the jungle of small ads on the World, in the health section, find the advertisement: "For Sale" Viagra ", each number !!!!!! E-mail: viagra@xxx.xxx To purchase a Forward-mail !!!!!!! ! (original spelling, e-mail address changed). The same author bear next announcement from the telephone and guarantees full discretion. Sending a letter - I wait a week and nothing. Electronic settlement of the case got stuck in a deadlock. I call the listed numbers. What is it: you can buy Viagra without a prescription from a person who allegedly bought the drug in the U.S. on prescription. The price is fixed - $ 25 (90 zł) per tablet 50 or 100 mg. Method of delivery - such as cash on delivery. Mailing list and message board, from a web page, therefore, served only as one of the media announcements, the authors simultaneously (or rather especially) since uploaded them in the press. In the first case, the creator of the advertisement on the list was the brother-selling drug in the second - an ingenious friend "entrepreneur". The next step is online shops. On the The Pill Box Pharmacy (http://www.thepillbox.com) Viagra can be ordered from throwing the appropriate packaging for virtual shopping basket. But before we do that, the party gives us a detailed description of the drug, its operation, instructions for use, and answers to basic, frequently asked questions. After reading this information should you wish to go to try this for fun thing. Free bottle of tablets here from 105.09 USD for 10 tablets to 304.39 for 30 tablets . Please also note the shipping costs and tax items with a value above $ 200. Viagra is a prescription, so the legal, such as this page are not we buy it "for beautiful eyes." That our contract was executed, we need to fax a prescription before the stated number. Only after the verification of our prescription order will be completed - payment card to pay and sent parcel. And if you do not want to run to the doctor? Calmly - in America, everything can be settled online. Pill Box recommends a web page, where you can ask your doctor for prescription of Viagra. If he prescribes to us the specific, once we ordered it. Oh, and a trifle - on-line consultation costs $ 85. The Pill Box Pharmacy is one of the most professionally prepared, inter alia, selling services Pfizer specific. Sometimes there many Europeans, and shows that at the top of the proposal to translate content on lang. German, French, Spanish, Italian and Portuguese. However, the shipment of Viagra outside the United States has some limitations. The medicine is sent only in their original bottles - 30 tablets each. The cost of such bottles is 305 USD, which gives 35 zł per tablet. Fort allow customs to be shipped to Hong Kong, Israel, Netherlands, France, Spain and Sweden only if you have a license of the importer. Germany and Austria Viagra is sent directly to pharmacies. It can also be sent to the individual, but the package must acknowledge receipt of pharmacy. If you buy less than 90 tablets, and live in Austria, France, Spain or Sweden, it's better to go to the page UKYes.com, advised The Pill Box Pharmacy. At this address until June 18, housed the British company offering Viagra. Unfortunately, after this date can be read there was that, in accordance with the wishes of Medicines Control Agency, the United Kingdom site is under construction ... Currently, all eager are sent to the Pill Box and asked the natives call. Fucking, HOLIDAYS AND MEXICO SKI DOCTOR No Frills Pharmacy (http://www.nofrillspharmacy.com) Nebraska (U.S.) offers a dose of Viagra 50mg now for U.S. $ 5.95 (4 euro). They argue that one dose of 10 bucks is too much, so they are so nice ... It looks suspiciously cheap. Checking, what's the catch, anywhere on the page do not write because of the tablets, only doses. Bingo! - Offer low cost due to the fact that instead of taking one tablet of 100 mg, can I cut to / / half and have two 50 mg! Price 100 mg tablets is the same as the "fifty" - the profit is evident. Of course, you need a prescription - you can fax it to them or give namiary to your doctor (with the license of the profession in the United States). They themselves have already confirmed that Viagra is we really zaordynowana. But when asked if they send Viagra to Polish, I received a reply that the Federal Agency for Medicines can not send this specyfiku outside the United States. J & D Pharmacy (http://www.jdpharmacy.com) is a virtual pharmacy of Missouri (USA), housed in a familiar-sounding town of Warsaw. Of course, you can buy Viagra here, but only (written in big red letters) with a prescription printed by an American doctor. "No exceptions!" - Add and repeat it even in several places. No consultation telephone and internet, so doctors do not work. But - if you live outside the U.S., you can use the services to open their new branch "Medical Wakacji. Discreet trip to Missouri will visit a specialist and receive the appropriate prescriptions. It also provides a typical tourist entertainment, accommodation, breakfast and lunch every day - prices starting at U.S. $ 749 per four-day trip for two people. Americans buy prescription drug on this site is somewhat lower than the standard price - U.S. $ 9.5 per pill (7 euro). American network of pharmacies Pro-Mark Pharmacies (http://www.pro-mark-pharmacies.com) sells Viagra prescribed not only by the U.S., but also by the Canadian or Mexican doctor. Price 8.5 USD (30 zł) per tablet when ordering 20 pieces. Giving hope to complete specialization http://www.viagrapharmacy.com page advertises free delivery to home and confidential ordering process. However, ordering on-line boils down to print the verification form for the authenticity of the medicine prescribed by your doctor. The same order must be made by phone ... The proposal is one - Pole was not so easy to buy Viagra over the Internet. Will indeed notice mailing list or bulletin board, but as well it might find itself in the daily newspaper. Will flood U.S. "BLUE BLOOD"? Pharmacies are not the only shops on the internet, which benefit from demand for new Pfizer drug. Giving the search for 'Viagra', we find many links to sites with various accessories and resources to advertise as a substitute or support for Viagra. They expect to potentially new customers, who after taking the blue pills regained sexual performance. For example, on page http://www.grannywouldnt.com/VIAGRTOY.html recommend a full set of erotic gadgets: from rings, creams delaying the peak. Creators http://www.hypnovision.com time went on the assumption that, if Viagra is needed in addition to appropriate stimulation, can they recommend a special audio - Tape Viagra. It is "mentally assist" users of Viagra and help them overcome the frustration associated with recent impotence. On the success of Pfizer to market the pill many want to earn some extra money. Whoever finds the least potential link with Viagra - is placed on your website to viagroamatorzy also looked to him. How big is this phenomenon, it is difficult to estimate. One thing is certain, however - Viagra is a revolution in the treatment of impotence and sexual life of people. Historically - the sexual revolution brought about through the humble blue tablets may be larger than expected (and was identified many years of XXI century) the technological revolution. Note: Prices in U.S. dollars British pound exchange rate, brand, and the dollar in June 1998 This text was made in late June and July, since then, so the status of Viagra in the country have changed. WEB DESIGN http://www.viagra.com - the official site for Viagra. Comprehensive information for professionals: description, composition, clinical pharmacology, interactions, dosage, etc. http://www.pfizer.com - the official site of the manufacturer of Viagra. http://www.thepillbox.com - The Pill Box Pharmacy - online pharmacy recently specializing in Viagrze. The possibility of consulting a doctor in cooperation with the Worldwide Inc. Medicine. and possible realization obtained where a prescription drug Pfizer. http://www.worldwidemedicine.com - medical advice to the web. Cooperate with The Pill Box Pharmacy, prescribing Viagra online. http://207.71.21.129 - UKYes.com party, the British company, which sold over the Internet in Europe willing Viagra. Closed in mid-June by the British Medicines Control Agency. From that moment, individual customers are sent to the Pill Box ... http://www.nofrillspharmacy.com - cheap 50mg dose of Viagra. Here tablets 100 mg are divided into two parts. http://www.jdpharmacy.com - J & D Pharmacy is another virtual pharmacy that sells Viagra. Her specialty is "Medical Vacations" - all outside the U.S. who wish to acquire Pfizer's prescription drug. http://www.pro-mark-pharmacies.com - home network pharmacies, selling Viagra prescription doctors consider U.S., Canadian and Mexican. http://www.viagrapharmacy.com - nice domain name, but the order comes down to phone orders. http://www.grannywouldnt.com/VIAGRTOY.html - sexshop network, a large selection of sex toys, now recommended for users of Viagra. http://www.hypnovision.com - shop Buyer various tapes with recordings, which are apparently hypnotic effect on audiences. Where to buy "Viagra tape. Truth and myths about Viagra: 1. Viagra is the modern aphrodisiac. True - Viagra for impotence is a medicine and should not take it up without consulting your doctor. Legal route is only available on prescription. 2. The only side effect is "seeing blue". Not true, but there are still visual headache (16% of respondents), flushing (10%), nausea (7%), swelling of the nasal mucosa (4%), urinary tract infections (3%), diarrhea (3% ), dizziness (2%), rash (2%). Same blurred vision - changes in luminance or blue glow - occur in 3% of respondents. Side effects are not uncommon and occur in the case of most drugs. However, Pfizer is working on the next generation of the drug, which will be devoid of side effects. 3. Viagra has been approved by the Vatican. True - acceptance, however, is unofficial. Apparently recognized that this is a drug with a positive impact on the family. 4. Viagra works equally well for women - experts here divided into two camps - some say it's not a woman, and others - that also allows you to change the experience of representatives of the fair sex. Pfizer is working on a version of Viagra for women, and the final product is to be ready in two years. 5. Viagra works immediately after taking the pills. Not true - the medicine starts to work in the period from 30 to 60 minutes after ingestion. Pfizer is working on a new variant of the drug, which will be absorbed from the tongue, and the time needed for the reaction will be reduced to several minutes. 6. Viagra is the only drug for impotence. Not true, there are many other measures and treatments for men treating this ailment. However, Viagra is the only one who, after oral ingestion gives as good results. 7. Viagra helps all impotentom. Wrong. During the studies at Boston University confirmed the effectiveness of the drug in 70% of cases. 8. After taking Viagra had died six men. Wrong. Pfizer maintains that the drug is safe, and the men's deaths have occurred for other reasons and had nothing to do with the intake of Viagra. Among the more than one million people taking the blue tablets should not be strange. Let us remember that in most of the drug does take older men aged 50-70 years. The big problem with anti-spam software and email accounts is that many emails, some which you may be expecting can get put into the blocked folders unintentionally.Now the question is buy Cialis. That is why Cialis also wears the popular label of the weekend pill. Marriages and relationships can also deteriorate because of the lack of intimacy. Generic Viagra and generic Cialis are as safe and as efficient as the brand name analogous products are.To improve your chances for successful smoking cessation, set a date to quit smoking. If you wish to discuss any of the above issues in more detail, do not hesitate to contact info@firstmed. Rimonabant Acomplia is not yet approved for smoking cessation treatment, but is available with prescription for weight loss treatment in USA, UK, Canada and European countries. A 20 milligrams dose of Cialis has the same effects a 100 milligrams dose of Viagra would have. Companies such as GlaxoSmithKline, Novartis, Roche Group, Pfizer, and Johnson & Johnson manufacture them. Follow your doctor's instructions.co.Anti-spam software has been utilized by millions to combat the irrelevant and sometimes crude advertising that fills their business and personal inboxes.Doctors Viagra say the government's decision to ration oral ED treatments such as Viagra, Levitra and Ciais is arbitrary, "bizarre" and unfair and does not go anywhere to meeting clinical need for the majority of impotent men. Men, feeling deterred from visiting their GP because they do not think they will get treatment could go undiagnosed of more serious conditions such as cardiovascular disease. This is because there are originator brands as well as generic brands of medicines. Take this medicine Chantix with a full glass of water. What to do about spam has been highly debated and a huge market exists to block spammers. The active ingredient used here is Tadalafil. 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THE LOWEST PRICES! cialis and levitra viagra online pharmacy cheap cialis pharmacy online cialis soft tabs online pharmacy online pharmacy generic cialis cialis online pharmacy carisoprodol cialis certified online pharmacy online pharmacy cialis pills generic cialis and us online pharmacy cialis overnight online pharmacy viagra cialis online pharmacy online pharmacy cialis cialis viagra online pharmacy online pharmacy viagra cialis levitra manufactures cialis online online pharmacy prescription soma buy cialis pharmacy online cialis and online pharmacy cheap cialis buy pharmacy online now cialis online pharmacy buy cialis generic pharmacy online generic cialis online pharmacy online pharmacy cialis on line generic cialis uk online pharmacy online pharmacy meds cialis buy cialis online pharmacy cialis nabp certified online pharmacy online pharmacy generic cialis pills cialis canada online pharmacy viagra buy cialis specialized cialis online pharmacy canadian cialis online pharmacy cialis generic pharmacy online cialis cheap online pharmacy buy cialis online pharmacy online cialis online online pharmacy cialis no prescription best online pharmacy viagra cialis online pharmacy satisfaction guaranteed cialis and us online pharmacy buy cialis online cheap pharmacy here Sildenafil (English and INN sildenafil citrate, ATC: G 04 BE 03, the original trade name: Viagra) - a medicine used to treat erection problems and Pulmonary hypertension in the original (in this indication under the name Revatio). It was patented in 1996 by Pfizer, and introduced for the first time on the market in 1998. Trade name of Viagra comes from sanskryckiego word wjaghra (Devanagari: व्याघ्र), identifying the tiger [1]. When you find a method to circumvent the patent Pfizera in this connection, it began to produce many companies in the world. Some of these are generic Kamagra (Ajanta Pharma) and the Polish Maxigra (Polpharma). There are also preparations wardenafilu (Levitra, Bayer) and tadalafilu (Cialis, Lilly) for similar action. Sildenafilu tablets contain 25 to 100 milligrams citrate this connection. The mechanism of action sildenafilu is inhibiting the enzyme fosfodiesterazy type 5 (PDE5) (affinity for other fosfodiesteraz is much smaller: PDE3 - more than 4,000 times, PDE 2, 3, 4, 7, 8, 9, 10, 11 - more than 700 times, PDE1 - 80 times, PDE 6 - 10 times). The molecule contains a recital sildenafilu piperazine and structural analogue of the principle of heterocyclic nukleozydowej, guanine - 1H-pyrazol [4.3-d] pirymidynę. Central phenolic system is structurally equivalent ribose, while the rest corresponds to the sulpho nucleotide phosphate. Desirable to take action Viagra leaflet with information about the proper use of medicine In people with a medical indication of sildenafil makes it possible to achieve sustainable wzwodu allowing completion of satisfactory sexual intercourse. Erection does not appear automatically after taking the medicine, but requires the erection normal sexual stimulation, which is its great advantage as compared with prostaglandin preparations. Keep eat from hours to 6 hours before the scheduled time relationship. In people with difficulties in erekcją doctor assesses the degree and nature of these difficulties and if they are actually a neurological psychiczno-recommended dose of the medicine that causes the persistence of wzwodu the normal time for a healthy man - that is, from 30 minutes to an hour. The medicine does not help people who have difficulty with erection different nature, for example resulting from the disappearance of the bodies of jamistych penis or low blood pressure. Another indication for use sildenafilu are selected cases of pulmonary hypertension. It has been shown that sildenafil can reduce the symptoms of pulmonary hypertension and improve tolerance effort. It is used when patients of all ages - including infants who have pulmonary hypertension may occur in the course of congenital heart defects. However, keep in mind about the possibility of complications of the treatment of blindness, including (vide contraindications). In a study SUPER, demonstrated significant improvement in the capacity stress in patients taking sildenafil at a dose of 20, 40 or 80 milligrams 3 times a day and this effect was independent of the applied dose of [2]. In Europe, the medicine has been registered for the treatment of pulmonary hypertension in functional class III and run as a form of idiopathic or connective tissue diseases [source needed]. Sildenafil at doses registered for the treatment of pulmonary hypertension is called Revatio. In two large randomized clinical trials on a group of 781 women with sexual dysfunction from normal (577 patients) and reduction (204 patients) the level of estrogen, there were no clinically significant improvement after taking doses sildenafilu (10-100 mg) compared with placebo. Contraindications It is contraindicated in the following diseases and states: * Ischemic heart disease, * Low blood pressure (less than 90/50 mmHg), * Simultaneous use of drugs from the group nitratów (nitrogliceryny, monoazotanu and diazotanu izosorbidu) * Allergic to sildenafil, * Severe liver and kidney failure, * After recently covered by the stroke or myocardial infarction, * In retinal degenerative changes, such as retinitis pigmentosa. Caution should be exercised in the following cases: * In patients with anatomical defects penis (Peyroniego disease, the bodies of jamistych fibrosis), * Patients treated ritonawirem, * Patients receiving α-adrenolityki, * In patients with a tendency to priapizmu (sickle cell anemia, multiple myeloma, other). Medicine should not be used in people from 18 years of age. This is a category B drug, which means that it is not intended for use in women, especially pregnant and lactating mothers. Side effects Side effects occur relatively infrequently, and these are not the most prevalent serious: * Headache, * Muscle pain, * Nausea, * Vomiting, * Feeling clogged nose, * Feeling hot in the vicinity of the face, * Transient visual disturbances, More serious side effects occur very rarely. Dyspeptyczne disorders, headaches and skin redness napadowe face combined with a feeling of hot (flushing) associated with the inhibition of fosfodiesterazy type 5 Due to the fact that sildenafil is blocking the enzyme retinal rodopsynazę (fosfodiesterazę type 6) side-effect of consumption sildenafilu may be changes in the reception colors (blue vision) [4]. On the other hand, due to the fact that fosfodiesteraza is present in all smooth muscles, including the heart, in patients with cardiac arrhythmia, hypertension and their tendency to zawałów, especially in combination with other drugs affecting the secretion of nitric oxide by the sympathetic nervous system, can claim to serious complications including myocardial infarction and death. The mechanism of drug action The mechanism of action sildenafilu At the time of the sexual arousal the brain sends a signal to the spinal nerve cells in the penis, controls the action of smooth muscle, which normally restrict the flow of blood through arteries to the penis jamistych bodies. Nerve cells, after receiving a signal from the brain, are beginning to produce nitric oxide. The smooth muscle is marked by a constant concentration of chemical compound - guanozyny triphosphate (GTP), and enzyme - guanozynowa cyclase. The enzyme is activated by nitric oxide produced by nerve cells. When activated, the enzyme that converts GTP in cGMP (cyclic monofosforan guanozyny). cGMP runs a string of change leading to a loosening of smooth muscle, thereby increasing the inflow of blood to the body jamistych member and his wzwodu. As long as the concentration of cGMP is maintained at a sufficiently high level, smooth muscle is relaxed, a member wzwiedziony. cGMP, however, is under normal conditions, constantly transformed by another enzyme - fosfodiesterazę - in the inactive GMP (plain monfosforan guanozyny). Hence the persistence of the penis is conditioned wzwodu constant cGMP production, and hence a constant delivery of nitric oxide by nerve cells, which must be driven by the brain. Many men, however, as a result of neuroses, mental tension, hormonal imbalances, or nervous system disorders współczulnego, production of nitric oxide by the nerve cell is too weak or short-term, leading to a weak and too short-term wzwodów. Sildenafil works by inhibiting an enzyme fosfodiesterazy. Sildenafil has a geometric shape similar to cGMP and well located in the center of the active fosfodiesterazy, however, involves the fosfodiesterazą for a long time, blocking the opportunity to catalyze the transition cGMP in normal GMP. As a result, even small "production" NO by nerve cells is sufficient to achieve the appropriate concentration of cGMP, and can maintain it even without the continued production of nitric oxide by these cells. However, thanks to the fact that sildenafil acts on the "final" stage of the process, it does not automatically wzwodu, but still needed for this is "normal" erotic stimulation. 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It is for men who have erection problems as a member of a total lack of wzwodu or loss in the event of sexual abuse. The active substance of Levitra is Vardenafil, which is manifested in the increased activity ukrwienia body jamnistego member. Levitra is not afrodyzjakiem. In men who zażyli preparation Levitra erection does not occur without sexual arousal. Vardenafil, the active substance of Levitra, starts its operations about 30 minutes after taking tablets. Duration of Levitra lasts about 12 hours, which is longer than the time the action of Viagra (and preparations generic Kamagra tablets and Kamagra in a gel), while less than action prepratu Cialis (and its preparation denerycznego Tadalis). Use of Levitra may have for each other undesirable side effects, such as: + Headache + Facial flushing, + Disorder blood supply to the eyes. Therefore, prior to the decision on the use of Levitra, as a means to increase the potency, it is a medical specialist. What is Levitra? Preparation Levitra is a medicine containing the active substance wardenafil. It is available in the form of round, orange tablets and contain the active substance wardenafil (5, 10 or 20 mg). To what purpose, the preparation Levitra? Preparation Levitra is used to treat disorders erekcyjnych (sometimes referred to as impotence) u adult men, based on inability to obtain or maintain wzwodu penis (erection) sufficient for a satisfactory sexual intercourse. The condition of the effectiveness of Levitra is sexual stimulation. It is available only on prescription. How is the preparation Levitra? The recommended dose of Levitra is 10 mg, taken together with or independently from him to be around 25 to 60 minutes before sexual activity. Beginning action of Levitra may be delayed if the medication is accompanied with wysokotłuszczowym. Depending on the effectiveness and side effects dose of the medicine can be increase up to a maximum of 20 mg or decreased to 5 mg. Patients with dysfunction severe liver or renal impairment should begin treatment with a dose of 5 mg. The maximum recommended frequency of application is one tablet a day. How does Levitra? The active substance in Levitra, wardenafil, belongs to a group of drugs known as inhibitors fosfodiestaryzy 5 (PDE5). Wardenafil inhibits the enzyme fosfodiestyrazy, which normally causes disintegration of substances known as cyclic GMP (cGMP). During normal stimulation sexual cGMP is produced in prąciu, where it causes smooth muscle diastole bodies jamistych (corpora cavernosa), allowing a greater inflow of blood to the body jamistych, causing erection. Inhibiting cGMP dissociation, Levitra restores normal erection. Wzwodu need to call is still sexual stimulation. The preparation as Levitra? Preparation Levitra studied in the four major studies involving 2,431 patients aged 20 do83 years in which it was compared with placebo (a neutral). One study performed in patients with diabetes, and other patients after prostatektomii (in men, which removed the prostate gland). The main measure of effectiveness was its ability to obtain and maintain erection. The information recorded in the two questionnaires completed at home. What benefit has been observed in studies Levitra? In all studies, preparation, Levitra has proved to be in all respects much more effective from placebo. What is the risk associated with the use of Levitra? The most common side effects associated with the use of Levitra (seen in more than 1 patient in 10) are headache and facial flushing. Full list of actions adverse events reported in connection with the use of Levitra is in a leaflet for patient. Preparation Levitra should not use a person who may be hypersensitive (allergic) to wardenafil or any other ingredients, and which is not desirable Sexual activity (for example, men with severe cardiovascular diseases, such as unstable gland piersiowa or severe heart failure). Preparation Levitra should not also accept patients who suffered loss of vision caused by impaired blood flow to the optic nerve in the eye (front ischemic optic nerve neuropathy - NAION). Is contraindicated acceptance of Levitra with nitrates (drugs used to treat angina). Because of Levitra has not been studied on patients with severe liver or kidney failure, not should be used, patients with impaired blood pressure, or who have a stroke or a heart attack over the past six months. Contraindicated simultaneous use of Levitra with certain drugs such as ketoconazole and itraconazole (medicines przeciwgrzybiczne) or ritonavir and indynawir (used to treat infections HIV). Why approved Levitra preparation? The Committee for Medicinal Products for Human Use (CHMP) decided that the benefits of the use of Levitra the risk associated with treatment of men with impaired erection. The Committee recommended the granting of an authorization of Levitra on the market. Other information about the preparation Levitra: On 4 March 2003, the European Commission granted Bayer AG authorization Levitra preparation for a marketing authorization valid throughout the European Union. Authorization renewed the market on 6 March 2008 Levitra - use, dosage * Author: admin * Filed under: Levitra Uses drugs Levitra (Wardenafil) is an oral therapy to treat erection problems. This is fosfodiesterazy inhibitor, which works by helping blood flow to the penis to achieve and maintain erection. How Taken Levitra should be taken as necessary, for about an hour before the start of sexual activity, but some form of sexual stimulation is needed for the erection occurs generic Levitra. Levitra should not be taken more than once a day. The omission of the dose Levitra is used as needed, so it probably will not miss any doses. Storage Store at 25 degrees C (77 ° F); authorized the trip to 15-30 degrees C (59-86 ° F). Levitra and keep all medicines out of reach of children. Warnings / Precautions Do not use Levitra if: * The patient is allergic to any ingredient in Levitra; * The patient takes or using nitrogliceryny (such as tablets, patches, ointment), nitrates (eg Isosorbide) or certain medications (eg Amiodarone, quinidine); * You have had a heart attack, stroke, or life-threatening irregular heartbeat during the past 6 months; * Do you have some problems with the eye (for example, diseases such as retinitis pigmentosa volleyball), uncontrolled chest pain, uncontrolled high blood pressure, low blood pressure, irregular heartbeat (such as congenital prolongation of the QT interval), severe heart failure, severe abnormal liver function, or end-stage kidney disease that requires dialysis. Contact your doctor or health provider immediately if any of these apply to you. Possible side effects If you experience any of the following serious side effects, you should discontinue use and seek medical assistance in an emergency or to tell your doctor immediately: * An allergic reaction (difficulty breathing, throat closing, swelling of lips, tongue or face, or urticaria); * Pain in the chest or irregular heartbeat; * Swelling of the ankles or legs; * Shortness of breath; * Long-term or severe dizziness; * Extended transmission (lasting longer than 4 hours) or painful erection, or * Dizziness, nausea, or angina (pain, pressure, discomfort, numbness or tingling in the chest, arm, neck or jaw). Other, less serious side effects may be more likely to occur. He continued to take Levitra and talk to your doctor if you develop * Redness; * Mild dizziness; * Headache; * Mucosal nasal congestion; * Diarrhea; * A temporary blue tint in vision or other visual disturbances, or * Itching or rash. Side effects other than those listed here may also occur. Talk to your doctor about the side effect that seems unusual or that is particularly annoying. More information Generic Levitra (Wardenafil) is available with a prescription under the brand name Levitra. Other brand or generic formulations may also be available. Ask your pharmacist you have any questions about this medication, especially if it is a novelty for you. Vi